Medical manufacturing company Fujifilm Diosynth Biotechnologies has taken 15,000 sq ft of space at The Wilton Centre in Redcar.
The move represents one of the 75-acre science park's most significant lettings with the business taking two floors at the site.
It also follows Faraday Training Group taking 36,000 sq ft at the Wilton Centre earlier this year.
"This is great news for Fujifilm, the Wilton Centre and the whole of Teesside, with the expansion of a world leading company in the region," said Steve Duffield, site director at the Wilton Centre.
"Fujifilm is exactly the sort of occupier we want to attract to the Wilton Centre to make use of our unique combination of office, laboratory and process development space.
"The centre's owners Angelo Gordon and Trinity Investment Management, which acquired the business park in March 2016, are especially keen to see leading scientific research and development businesses at the Wilton Centre and at their other science and technology parks in the UK."
Paul Found, chief operating officer of Fujifilm Diosynth Biotechnologies, added: "Our expansion into Wilton has allowed us to efficiently increase our development capabilities in the UK.
"Wilton offers us access to high quality laboratory space with great supporting infrastructure which are critical to effectively meet our customers' needs."
Middlesbrough-based Dodds Brown acted for the Wilton Centre, while Fujifilm Diosynth Biotechnologies was unrepresented.